DEVELOPMENT OF TECHNOLOGY FOR OBTAINING SUPPOSITORIES USING ADYRASPAN RAW MATERIAL

Abstract

More than six thousand plant species grow in Kazakhstan, and approximately five hundred of them are classified as medicinal plants. The common adyraspan plant was selected as the object of this study, and information about its medicinal properties was collected and analyzed. The chemical composition of the adyraspan plant was investigated. In addition, a diagnostic examination of the plant roots was carried out, and the identification of the raw material confirmed the presence of alkaloids in its chemical composition.

Optimal conditions for the extraction of the alkaloid complex from the plant were determined during the research. Harmine alkaloids were identified using thin-layer chromatography. The results showed that the most efficient method, in terms of yield, was the isolation of alkaloids from adyraspan seeds in the presence of sulfuric acid.

Furthermore, based on the extract obtained from the common adyraspan plant, a technology for the preparation of suppositories was developed using cocoa butter as a base and a manual mixing method. Additional studies were conducted to evaluate and establish the quality criteria of the resulting pharmaceutical product.