RESEARCH ON THE DEVELOPMENT OF TECHNOLOGY FOR OBTAINING DOSAGE FORMS FROM POLYMER GELS

Abstract

One of the main directions of pharmaceutical development is to expand the range of existing dosage forms of active ingredients, aimed at reducing the side effects of active ingredients and increasing ease of use. In addition, medicines should ensure the fastest and most complete release of active substances from dosage forms and the penetration of active substances into the target organ, including when applied topically. When developing drugs with antibacterial action, much attention is paid to the spectrum of antimicrobial activity and the level of resistance of pathogenic bacteria to active substances. The high level of resistance of modern strains of microorganisms to antibiotics limits the use of many already known active substances. In this regard, an urgent task is to develop antimicrobial drugs, the mechanism of action of which differs from antibiotics, which have proven their effectiveness and are convenient to use. Such drugs include drugs based on nitrofuran derivatives. This class of compounds is widely used both for oral administration and as external antiseptics in inpatient, outpatient, and home settings. Representatives of the chemical group of nitrofurans are widely used for topical use-nitrofural and furazolidone, which are broad-spectrum antibacterial agents effective against Gram-positive and Gram-negative bacteria.